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GenomicsGlobal views of leukaemia : Article : Nature

Citation added: April 13th, 2007, 2:04 pm
Genomic characterization of a type of leukaemia has resulted in the identification of common genetic abnormalities that underlie the disease. The results constitute an advance on several fronts.
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Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia : Article : Nature

Citation added: April 11th, 2007, 10:57 am
The PAX5 gene was the most frequent target of somatic mutation, being altered in 31.7% of cases. The identified PAX5 mutations resulted in reduced levels of PAX5 protein or the generation of hypomorphic alleles. Deletions were also detected in TCF3 (also
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A Five-Gene Signature and Clinical Outcome in Non-Small-Cell Lung Cancer

Citation added: January 4th, 2007, 7:34 am
"Our five-gene signature is closely associated with relapse-free and overall survival among patients with NSCLC."
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Genomic signatures to guide the use of chemotherapeutics - Nature Medicine

Citation added: November 7th, 2006, 11:18 am
The development of gene expression profiles that can predict response to commonly used cytotoxic agents provides opportunities to better use these drugs, including using them in combination with existing targeted therapies.
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The challenges of gene expression microarrays for the study of human cancer

Citation added: May 16th, 2006, 6:31 am
Cancer Cell: " This review considers the promise and challenge associated with the large-scale clinically oriented genomic analysis of human cancer and attempts to emphasize potential solutions. "
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