Effector Function of Human Tumor-Specific CD8 T Cells in Melanoma Lesions: A State of Local Functional Tolerance -- Zippelius et al. 64 (8): 2865 -- Cancer Research

Citation added: April 26th, 2006, 2:28 pm
Romero/pittet paper on Melan-A specific T cells: "whereas primed Melan-A/MART-1-specific CD8 T cells that circulate in the blood display robust inflammatory and cytotoxic functions, those that reside in tumor lesions (particularly in metastatic lymph node
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Toward improved immunocompetence of adoptively transferred CD8+ T cells -- Speiser and Romero 115 (6): 1467 -- Journal of Clinical Investigation

Citation added: April 26th, 2006, 12:27 pm
Speiser review in JCI. "it remains difficult to precisely define the optimal differentiation stages of T cells most suitable for ACT."
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Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells -- Klebanoff et al. 102 (27): 9571 -- Proceedings of the National Academy of Sciences

Citation added: April 26th, 2006, 12:16 pm
Restifo/Rosenberg article: "we used an established model for the in vitro generation of TCM and TEM by using IL-15 and IL-2, respectively. Adoptively transferred TCM exhibited a potent in vivo recall response when combined with tumor-antigen vaccination a
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Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells -- Gattinoni et al. 115 (6): 1616 -- Journal of Clinical Investigation

Citation added: April 26th, 2006, 12:14 pm
Restifo JCI paper. Multiply stimulated TG-t cells. "While the progressive acquisition of terminal effector properties is characterized by pronounced in vitro tumor killing, in vivo T cell activation, proliferation, and survival are progressively impaired
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Programming CD8+ T cells for effective immunotherapy

Citation added: April 26th, 2006, 10:25 am
Restifo review article: Understanding the mechanisms that control CD8+ T-cell differentiation is important in the development of novel immunotherapy strategies.
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