Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer : Abstract : Nature

Citation added: August 1st, 2007, 11:10 am
Because the common factor of these rearrangements is aberrant ETV1 overexpression, we recapitulated this event in vitro and in vivo, demonstrating that ETV1 overexpression in benign prostate cells and in the mouse prostate confers neoplastic phenotypes.
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chinnaiyan | microarray | predictor | cancer | j.nature

GenomicsGlobal views of leukaemia : Article : Nature

Citation added: April 13th, 2007, 2:04 pm
Genomic characterization of a type of leukaemia has resulted in the identification of common genetic abnormalities that underlie the disease. The results constitute an advance on several fronts.
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j.nature | references | golub | microarray | cancer | mq

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia : Article : Nature

Citation added: April 11th, 2007, 10:57 am
The PAX5 gene was the most frequent target of somatic mutation, being altered in 31.7% of cases. The identified PAX5 mutations resulted in reduced levels of PAX5 protein or the generation of hypomorphic alleles. Deletions were also detected in TCF3 (also
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references | j.nature | microarray | all | cancer

Prediction of central nervous system embryonal tumour outcome based on gene expression : Article : Nature

Citation added: March 13th, 2007, 7:27 am
Here we demonstrate that medulloblastomas are molecularly distinct from other brain tumours including primitive neuroectodermal tumours (PNETs), atypical teratoid/rhabdoid tumours (AT/RTs) and malignant gliomas. Previously unrecognized evidence supporting
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j.nature | golub | pomeroy | predictor | microarray | cancer | mq

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